NAD+

What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme found in all living cells. NAD+ is a crucial molecule that supports many fundamental biological processes, from energy production to cellular repair and regulation. Its significance in maintaining cellular health and its potential in extending healthspan and lifespan make it a prominent focus of research in aging and metabolic health.

Benefits

• Improved Skin Elasticity and Firmness
• Enhanced Cellular Regeneration
• Increased Hydration
• Antioxidant Protection
• Reduced Inflammation

Mechanisms of Action

Topical NAD+ (nicotinamide adenine dinucleotide) operates through several mechanisms to potentially improve skin health. Here’s a detailed look at how it works:

1. Cellular Energy Production: NAD+ is a crucial coenzyme involved in cellular energy metabolism. By applying NAD+ topically, it can be absorbed into the skin cells where it helps enhance ATP (adenosine triphosphate) production. ATP is the primary energy carrier in cells, and increased ATP levels can boost cellular processes, including repair and regeneration.

2. Cellular Repair and Regeneration: NAD+ plays a vital role in DNA repair and maintenance. Topical NAD+ may stimulate cellular repair mechanisms by facilitating the activity of enzymes involved in DNA repair, such as PARPs (poly(ADP-ribose) polymerases). This can help improve skin health by promoting the repair of damaged skin cells and reducing signs of aging.

3. Regulation of Sirtuins: NAD+ is a key regulator of sirtuins, a family of proteins that influence various biological processes, including aging and inflammation. Sirtuins help regulate cellular stress responses and longevity. By increasing NAD+ levels, topical application may activate sirtuins, which can enhance skin repair processes and reduce inflammation.

4. Antioxidant Defense: NAD+ supports the production of antioxidants and enhances the function of the body’s antioxidant defense systems. This helps combat oxidative stress caused by free radicals. Topical NAD+ can potentially reduce oxidative damage to skin cells, thus protecting the skin from environmental stressors and premature aging.

5. Improved Skin Barrier Function: NAD+ can help reinforce the skin’s barrier function by supporting the synthesis of structural proteins and lipids. A stronger skin barrier improves moisture retention and reduces transepidermal water loss (TEWL), leading to better hydration and overall skin health.

Directions

Apply twice daily to clean, dry skin. Gently pat into skin until fully absorbed. Do not apply directly to open wounds.