What is the Difference Between TB-500 and BPC-157?

What is the Difference Between TB-500 and BPC-157?

In terms of healing and recovery, both TB 500 and BPC 157 have very beneficial effects in animals.

Each peptide promotes enhanced recuperation from injuries to joints, bones, muscle, and connective tissue. Simultaneously, they each provide a protective effect against injury as well, promoting stronger musculoskeletal tissue with greater joint, tendon, and ligament flexibility.

Still, they do have significant differences in their respective origins and structures, along with some key variations in administration and which types of body tissue they most greatly affect.

First, let’s define each product.

TB 500 is synthetically produced Thymosin Beta 4, a protein produced by the thymus gland. It exerts its healing effects through several mechanisms, including the upregulation of actin, enhanced angiogenesis (blood vessel formation), and reduced inflammation.

On the other hand, BPC 157 is a synthetically made peptide similar to Body Protection Compound, a natural peptide found in the gastrointestinal tract that facilitates digestion and the healing of ulcers.

Though based on the natural Body Protection Compound, BPC 157 is a truly synthetic peptide in that its sequence does not occur in nature. This is in contrast to TB 500, which mirrors the structure of natural Thymosin Beta-4.

This distinction, as well as their origins and chemical structures, are the clearest differences between both peptides.


TB 500 and BPC 157 share several mechanisms of action in regard to enhancing healing and recovery. For example, BPC 157 also improves angiogenesis and cell survival and migration, all of which are central characteristics of TB 500.

Indeed, both peptides have been observed to exert powerful healing effects on injured muscle, joint, bone, and connective tissue in clinical study.

It’s clear that both products are effective. With that in mind, will one be better than another for promoting recovery in a specific animal?

This answer will often depend on the type and location of the injury, as well as some other factors. Let’s continue to examine this in the context of these products’ main characteristics.

TB-500 Vs. BPC-157

One key difference between the two compounds is administration (how the product is given to the animal).

TB-500 is commonly given once or twice per week with total weekly dosages of 10 to 20mg.

Conversely, BPC-157 is administered in dosages of 250mcg (0.25mg) to 1000mcg (1mg) daily. This means weekly dosages total 1.75mg to 7mg, significantly less than its counterpart.

Perhaps more importantly, TB-500 has a systemic effect, meaning it promotes healing in injured tissue throughout the animal’s body regardless of the location of administration.

BPC-157, however, has a localized healing effect. This means that it most greatly benefits injured tissue within close proximity to the site of administration.

Further, studies have shown BPC-157 to have powerful healing and protective effects in the gastrointestinal system and in neurological tissue. As a result, there is evidence that it is effective for promoting recovery and guarding against harm in these areas when given orally, even when its localized healing effects are taken into account. Read more about oral BPC-157.

Other Possible Differences

Anecdotally, some veterinary professionals have reported TB 500 to have greater benefits in animal muscle tissue than BPC 157. This pertains specifically to growth and strength promoting effects. On the other hand, many reports appear to indicate that both peptides have a similar (powerful) healing and protective effect on joint, bone, and connective tissue.

As a result, some animal trainers will choose TB 500 as an ancillary strength and growth promoting aid over BPC 157 when the goal is solely lean muscle development in the animal. At the same time, other veterinary professionals have reported slightly better injury healing results with BPC 157.

So why the difference, and what is really going on here?

Without a proper study performed in a clinical setting, it is difficult to say for sure. However, we can speculate that the difference is likely just natural variation in individual response; i.e., certain products simply work better for some animals than others.

Synergistic Effects

Importantly, an enhanced recovery effect is often observed in the animal when the two peptides are administered simultaneously, as both can work to stimulate healing through complementary mechanisms.

Therefore, stacking both peptides together can result in a potent synergy that provides the greatest growth and healing benefits.

That’s why Thymosin Labs™ created PROHEALIX™ - the optimal blend of TB 500 and BPC 157 for maximum veterinary recovery and performance. PROHEALIX™ offers an ideal blend of recovery peptides in one convenient product.

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